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Cohort studyCardiology in the young · 2026

Association of postoperative haemodynamic parameters with progression of left atrioventricular regurgitation in infants: leveraging high-fidelity data: a hypothesis-generating study.

Rohit Seth Loomba, Oscar Dominguez, Jamie Smith Penk … Michael Monge

CardiologyCohort study

32% of infants after atrioventricular septal defect repair developed worsening left atrioventricular valve regurgitation.

Association of postoperative haemodynamic parameters with progression of left atrioventricular regurgitation in infants: leveraging high-fidelity data: a hypothesis-generating study.

Rohit Seth Loomba … Michael Monge

Cardiology in the young · 2026

Background

The success of an atrioventricular septal defect repair depends largely on the function of the left atrioventricular valve.

Methods

A single-centre, retrospective study of infants less than 1 year of age admitted to the paediatric cardiac ICU following atrioventricular septal defect repair between January 2022 and May 2025 was conducted.

Results

32%

of infants developed worse heart valve leaking after heart surgery

More results

Haemodynamic parameters significantly correlated with worse left atrioventricular valve regurgitation were increased mean arterial blood pressure, increased blood pressure variability, and decreased cerebral and renal near-infrared spectroscopy.

More results

Of note, blood pressure variability had a greater association with worsening left atrioventricular valve regurgitation when compared to absolute mean arterial blood pressure.

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Conclusion

A high cardiac output, low systemic vascular resistance state with minimal blood pressure variability appears optimal to decrease impact on the left atrioventricular valve.

Post

Association of postoperative haemodynamic parameters with progression of left atrioventricular regurgitation in infants: leveraging high-fidelity data: a hypothesis-generating study.

32% of infants after atrioventricular septal defect repair developed worsening left atrioventricular valve regurgitation.

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