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Animal / preclinicalResults in engineering · 2026

Quantifying Local Strain Field and Deformation in Active Contraction of Bladder Using a Pretrained Transformer Model: A Speckle-Free Approach.

Alireza Asadbeygi, Anne Robertson, Yasutaka Tobe … Simon Watkins

UrologyAnimal / preclinical

New speckle-free method accurately tracks bladder deformation with low error.

Quantifying Local Strain Field and Deformation in Active Contraction of Bladder Using a Pretrained Transformer Model: A Speckle-Free Approach.

Alireza Asadbeygi … Simon Watkins

Results in engineering · 2026

Background

Accurate quantification of local strain fields during bladder contraction is essential for understanding the biomechanics of bladder micturition, in both health and disease.

Results

less than 1.5 pixels

the tracking method was very accurate, with minimal error in position

n = 4

More results

In this study, we introduce a speckle-free framework for quantifying local strain fields using a state-of-the-art, zero-shot transformer model, CoTracker3.

More results

Application to in vitro active bladder contractions in four rat specimens (n=4) revealed statistically significant anisotropy (p<0.01), with higher contraction longitudinally compared to circumferentially.

Multiphoton microscopy further illustrated and confirmed heterogeneous morphological changes, such as large fold formation during active contraction.

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Conclusion

This non-invasive approach eliminates speckle induced artifacts, enabling more physiologically relevant measurements, and has broad applicability for material testing of other biological and engineered systems.

Post

Quantifying Local Strain Field and Deformation in Active Contraction of Bladder Using a Pretrained Transformer Model: A Speckle-Free Approach.

New speckle-free method accurately tracks bladder deformation with low error.

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