Post

New research · Neurology
Neurology · 4d
ObservationalNeurology · 2026

Association of Sleep Variables With Cognitive Performance and the Risk of Dementia in the Sleep and Dementia Consortium.

Stephanie Yiallourou, Crystal Wiedner, Qiong Yang … Jayandra Jung Himali
Read paper
NeurologyObservational

Greater sleep quantity and efficiency is associated with better global cognitive performance.

Association of Sleep Variables With Cognitive Performance and the Risk of Dementia in the Sleep and Dementia Consortium.

Stephanie Yiallourou … Jayandra Jung Himali
Neurology · 2026
Background

Sleep is multidimensional, and it remains unclear which aspects are most relevant to cognition and dementia risk.

Purpose

We aimed to apply a data-driven approach to identify clusters of sleep variables that reflect meaningful sleep composites and examined their association with cognition and dementia risk.

Methods

Aged ≥45 and ≥60 years were included in the cognitive and dementia analyses, respectively.

n = 5,958 participants
Results
0.03
each unit of longer, more consolidated sleep was associated with a higher overall thinking ability
n = 5,958 participants
More results

The pooled cognitive analysis included 5,958 participants (mean ± SD age 70 ± 11 years, 32% female).

The incident dementia analysis included 5,471 participants (74 ± 12 years, 31% female).

More results

Nine sleep composites were identified, together explaining 49% of the total variance in the original 44 sleep metrics: Sleep quantity and efficiency, sleep fragmentation, light non-rapid eye movement (non-rapid eye movement) predominance, N3 predominance, spindle number and duration, REM sleep bouts, respiratory disturbances, slow oscillation-spindle coupling, and spindle amplitude.

“
Conclusion

These composites may be useful in guiding further investigations of sleep-brain health relationships.

Read paper
0 comments

No comments yet. Be the first.

Related papers

LatestFoundational
Cohort Study
OR 0.41
Odds of aneurysm rupture with anticoagulation were not significantly lower than single antiplatelet therapy.
Cohort Study
HR = 1.64
male officers had a higher rate of amyotrophic lateral sclerosis than enlisted personnel
Randomized Trial
16.2%
rivaroxaban led to a higher percentage of people with fewer migraine days than metoprolol
Study
more than 3.4 billion people
the global count of people living with brain and nerve conditions
Study
95%
most specialized training program leaders were open to a unified date for job offers
Case Report
81%
patients experienced lower nightmare frequency when taking once-nightly pregabalin
Cross-sectional
RR=1.72 (1.35-2.08)
Risk of Lewy body dementia diagnosis was 1.72 times higher in North East England.
Cohort Study
71.8%
children with D/EE-SWAS achieved freedom from seizures after taking ethosuximide