Impact of antithrombotic therapy on outcomes of incidental unruptured intracranial aneurysms in patients with ischemic stroke.
Anticoagulation was not associated with lower odds of aneurysm rupture.
Impact of antithrombotic therapy on outcomes of incidental unruptured intracranial aneurysms in patients with ischemic stroke.
The coexistence of acute ischemic stroke (acute ischemic stroke) and unruptured intracranial aneurysms (unruptured intracranial aneurysms) is relatively common, but the safety of antithrombotic therapy in this population remains uncertain.
This study evaluated whether different secondary prevention regimens influence unruptured intracranial aneurysms progression or rupture risk.
Were categorized according to long-term antithrombotic exposure: single antiplatelet therapy (single antiplatelet therapy), anticoagulation, or no regular therapy.
Odds of aneurysm rupture with anticoagulation were not significantly lower than single antiplatelet therapy.
Among 197 patients (mean age 68.4 ± 10.2 years; 53.8% female), 140 received single antiplatelet therapy, 36 received anticoagulation, and 21 received no regular therapy.
No ruptures occurred in the anticoagulation group.
In patients with small incidental saccular unruptured intracranial aneurysms and acute ischemic stroke, standard secondary prevention regimens were not associated with an increased risk of aneurysm rupture.
However, the limited number of rupture events and potential residual confounding warrant cautious interpretation. Secondary stroke prevention should remain the priority, with individualized assessment of aneurysm-related risks.