Longitudinal Behavior of the Hyper-Reflective Ganglion Cell Layer Band and Its Association With Ellipsoid…

Cohort studyInvestigative ophthalmology & visual science· Jul 2026

Longitudinal Behavior of the Hyper-Reflective Ganglion Cell Layer Band and Its Association With Ellipsoid Zone Constriction Rate in RP.

Alessio Antropoli, Rebecca Toscani, Giovanni Scalabrin … Maurizio Battaglia Parodi

RetinaCohort studyPrognosisQ1IF 4.2

Presence of the hyper-reflective ganglion cell layer band is linked to slower retinal thinning in retinitis pigmentosa

Longitudinal Behavior of the Hyper-Reflective Ganglion Cell Layer Band and Its Association With Ellipsoid Zone Constriction Rate in RP.

Alessio Antropoli … Maurizio Battaglia Parodi

Investigative ophthalmology & visual science · Jul 2026 · Q1 in Ophthalmology

Purpose

To investigate the longitudinal behavior of the hyper-reflective ganglion cell layer band (HGB) and its association with ellipsoid zone (ellipsoid zone) constriction over time in molecularly characterized RP, based on the hypothesis that the HGB represents a manifestation of inner retinal remodeling with potential prognostic significance.

Methods

We conducted a retrospective cohort study featuring patients with typical RP caused by variants in photoreceptor-associated genes and ≥6 months follow-up.

n = 118 eyes

Results

eyes with the marker lost retinal tissue more slowly than eyes without it

Eyes without HGB

6.4% per

Eyes with HGB

4.3% per

More results

HGB was detected at baseline in 27 eyes (22.9%) from 14 patients.

Over follow-up, no eyes developed or lost the HGB.

Compared with autosomal recessive RP (5.5% per year), ellipsoid zone constriction was significantly slower in autosomal dominant RP (2.8% per year; P = 0.0005) and faster in X-linked RP (7.7% per year; P = 0.021).

“

Conclusion

HGB is a relatively stable optical coherence tomography finding in RP and is associated with increased ganglion cell layer thickness and a slower rate of ellipsoid zone constriction.

Longitudinal Behavior of the Hyper-Reflective Ganglion Cell Layer Band and Its Association With Ellipsoid Zone Constriction Rate in RP.

Longitudinal Behavior of the Hyper-Reflective Ganglion Cell Layer Band and Its Association With Ellipsoid Zone Constriction Rate in RP.

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