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New research · Ophthalmology
American journal of ophthalmology · 5d
Cohort studyAmerican journal of ophthalmology · 2026

Systemic treatment with the ROCK2 inhibitor belumosudil in ocular chronic graft versus host disease.

Yibo Wu, Bei Ye, Xiaoyu Lai … Yi Luo
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OphthalmologyCohort study

Belumosudil was linked to improved eye disease severity in over half of patients with steroid-refractory graft-versus-host disease.

Systemic treatment with the ROCK2 inhibitor belumosudil in ocular chronic graft versus host disease.

Yibo Wu … Yi Luo
American journal of ophthalmology · 2026
Purpose

To evaluate the efficacy of oral belumosudil on ocular surface disease in patients with steroid-refractory chronic graft-versus-host disease (SR-cGVHD). median CFS decreased from 4 to 3, tear break-up time increased from 1.00s to 2.00s, and Schirmer's test improved from 1.0 mm to 2.0 mm.

Methods

In this retrospective study, we analyzed patients with SR-cGVHD and ocular involvement (oGVHD) treated with belumosudil (200 mg daily).

Results

eye disease got better for over half of patients treated

4
Before
3
After
More results

Among 78 treated patients, 40 had oGVHD; 28 completed both assessments.

The cohort (median baseline NIH eye score: 2; oGVHD severity score: 9) had high-risk cGVHD features: 50.0% had severe systemic cGVHD and 82.1% had conjunctival fibrosis.

“
Conclusion · 1 of 2

Systemic belumosudil was associated with improvements in ocular surface parameters and symptoms in steroid-refractory oGVHD, with favorable tolerability.

Conclusion · 2 of 2

Ocular improvement was closely linked to systemic response, warranting prospective validation.

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