Plasma Proteomics Identifies Proteins and Pathways Associated with Cataract: A Prospective Cohort Study.

Of the 2920 plasma proteins analyzed, 58 demonstrated significant associations with cataract risk ( P < 1.71×10 -5 , Bonferroni-corrected threshold).

Mendelian randomization analysis provided evidence supporting causal relationships for 4 proteins (CRYBB2, V-set and immunoglobulin domain-containing protein 4, mevalonate kinase, and metalloproteinase inhibitor 1) with cataract, with genetically predicted CRYBB2 levels showing a significant association with cataract risk, which is strongly supported by colocalization evidence.