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New research · Ophthalmology
Frontiers in medicine · 5d
AI / informaticsFrontiers in medicine · 2026

CLEAR report 1: a scoping review and meta-analysis for definitions, imaging metrics, and functional correlates of photoreceptor integrity in AMD.

Kimberly L Spooner, Anjali Gaston, Anushka Irodi … Dun Jack Fu
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OphthalmologyAI / informatics

Photoreceptor optical coherence tomography measurements are highly reliable when boundaries are clearly defined.

CLEAR report 1: a scoping review and meta-analysis for definitions, imaging metrics, and functional correlates of photoreceptor integrity in AMD.

Kimberly L Spooner … Dun Jack Fu
Frontiers in medicine · 2026
Background

Advanced age-related macular degeneration (AMD) is a leading cause of irreversible vision loss worldwide, with photoreceptor degeneration representing the final common pathway of functional impairment.

Purpose

Advanced age-related macular degeneration (AMD) is a leading cause of irreversible vision loss worldwide, with photoreceptor degeneration representing the final common pathway of functional impairment.

Methods

MEDLINE, Embase, and Scopus were searched from January 2015 to December 2025 following PRISMA-ScR guidelines.

ICC > 0.90
Results
ICC > 0.90
boundary measurements matched closely across repeated readings when clearly defined
More results

Ninety-four studies met inclusion criteria, spanning spectral-domain and swept-source optical coherence tomography platforms and diverse AMD phenotypes.

More results

Structure-function analyses demonstrated moderate-to-strong correlations between photoreceptor loss and microperimetry sensitivity ( r = 0.50-0.80) and best-corrected visual acuity ( r = 0.40-0.70), particularly in advanced disease stages.

“
Conclusion · 1 of 2

Optical coherence tomography-derived photoreceptor biomarkers show high analytical reliability and clinically meaningful structure-function associations when segmentation boundaries, analytic domains, and reporting conventions are clearly specified.

Conclusion · 2 of 2

However, the review identifies substantial construct heterogeneity that complicates cross-study comparability and endpoint interpretation.

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