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New research · Ophthalmology
Ophthalmology · 5d
Cohort studyOphthalmology · 2025

Glucagon-like Peptide-1 Receptor Agonist Impact on Chronic Ocular Disease Including Age-Related Macular Degeneration.

Kevin C Allan, Julia H Joo, Sonia Kim … Aleksandra V Rachitskaya
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OphthalmologyCohort study

GLP-1 diabetes drugs linked to lower risk of dry age-related macular degeneration

Glucagon-like Peptide-1 Receptor Agonist Impact on Chronic Ocular Disease Including Age-Related Macular Degeneration.

Kevin C Allan … Aleksandra V Rachitskaya
Ophthalmology · 2025
Purpose

This study investigated whether GLP-1RAs influence the risk for age-related ocular diseases.

Methods

This study used an electronic health records platform of patients in the United States.

n = 9669 patients
Results

Patients on GLP-1 drugs had lower rate of dry macular degeneration versus metformin users

HR 0.68 (95% CI 0.56 to 0.84)
null = 10.560.84
CI excludes the null - significant
More results

Of the 9669 patients taking GLP-1RAs, 84.4% had a diagnosis of diabetes with an average body mass index (BMI) of 36.2 kg/m 2 .

This significant reduction appeared after 3 years compared with metformin (HR, 0.69; 95% CI, 0.52-0.91), insulin (HR, 0.66; 95% CI, 0.5-0.87), and statins (HR, 0.67; 95% CI, 0.51-0.88).

More results

Notably, GLP-1RAs also significantly reduced the risk of exudative AMD (HR, 0.70; 95% CI, 0.58-0.84) and primary open-angle glaucoma (HR, 0.58; 95% CI, 0.45-0.76) compared with insulin after 3 years.

Use of GLP-1RAs showed no persistent impact on the risk of cataract formation or ocular hypertension compared with other medications.

“
Conclusion · 1 of 2

This study suggests that GLP-1RAs may reduce the risk of multiple age-related ocular diseases and the need for future prospective studies to validate these findings.

Conclusion · 2 of 2

FINANCIAL DISCLOSURE(S): Proprietary or commercial disclosure may be found in the Footnotes and Disclosures at the end of this article.

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