Temperature Excursion of Intravitreal Anti-VEGF Agents During Home Storage.
Nearly 3 in 10 patients let home-stored anti-VEGF eye drugs get too warm for 48+ hours
Temperature Excursion of Intravitreal Anti-VEGF Agents During Home Storage.
IMPORTANCE: Some patients worldwide are asked to acquire an anti-vascular endothelial growth factor (anti-VEGF) agent from a pharmacy, store it, and then bring it to a physician for intravitreal injection (IVT).
To investigate whether patients followed the storage temperature guidelines for intravitreal anti-VEGF agents in daily clinical practice.
DESIGN, SETTING, AND PARTICIPANTS: This quality improvement study, performed between May 27 and June 7, 2024, at the Ophthalmology Department of Dijon University Hospital in Dijon, France, included all consecutive patients with new or renewed prescriptions for intravitreal anti-VEGF agents for any macular disease.
checked ≥48 hours too warm at home before injection
During the study period, 50 participants were prescribed intravitreal anti-VEGF agents and were given a time-temperature indicator.
A total of 38 participants (24 [63.2%] female; median age, 79.3 [IQR, 74.3-86.3] years) returned for their IVT with an analyzable indicator.
Following anti-VEGF agent IVT, no participant experienced any ocular adverse effect that might be associated with severe intraocular inflammation.
In this quality improvement study, temperature excursions of anti-VEGF agents above 8 °C for 48 hours or longer were recorded for 28.9% of participants during home storage.
While it is unknown how these 38 participants relate to other patients worldwide who are required to obtain their own anti-VEGF agents, these findings suggest that patients need education about the importance of rigorous maintenance of cold storage of their anti-VEGF agents.