Smartphone-based offline AI for multi-disease retinal screening: Real-world accuracy.

For glaucoma (n = 109), sensitivity was 98.2% (95% CI: 94-100), specificity 99.0% (95% CI: 97-100), AUROC 0.99.

For AMD (n = 56), sensitivity was 88.9% (95% CI: 77-96), specificity 97.5% (95% CI: 95-99), AUROC 0.93.

For diabetic retinopathy (n = 78), sensitivity was 84.6% (95% CI: 75-92), specificity 99.0% (95% CI: 97-100), AUROC 0.92.

Agreement on vertical cup-to-disc ratio between AI and graders ranged from -0.1 to +0.1, with intergrader ICC of 0.97 (P < 0.001 for all comparisons).