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New research · Ophthalmology
PloS one · 5d
Cohort studyPloS one · 2026

Repeatability and reproducibility of a clinical device for Brillouin microscopy to measure the biomechanics of the anterior segment of the eye: In vivo tests.

Hannah Pearl Glucksman, Andrew Shin, Lawrence Yoo … Claire Shelley Barnes
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OphthalmologyCohort study

The Brillouin Optical Scanning System shows low variation in lens stiffness across devices.

Repeatability and reproducibility of a clinical device for Brillouin microscopy to measure the biomechanics of the anterior segment of the eye: In vivo tests.

Hannah Pearl Glucksman … Claire Shelley Barnes
PloS one · 2026
Purpose

We performed a prospective study to assess the repeatability and reproducibility of the novel Brillouin Optical Scanning System (BOSS®) in measuring the biomechanical properties of the cornea and crystalline lens in vivo, to determine device utility in a clinical setting.

Methods

Adult study participants underwent standard ophthalmic exams to confirm eligibility.

n = 33 participants
2.1%
Results
2.1%
this is the low variation in eye lens stiffness when measured by different devices
n = 33 participants
More results

Eleven of the 33 participants (ages 24-72 years; 15 females) had keratoconus (5 with prior crosslinking, 3 without crosslinking, and 3 post-keratoplasty); the other 22 participants were visually normal.

More results

The mean corneal stiffness was 2.83 ± 0.031 GPa, with an overall repeatability coefficients of variation of 1.1%, ranging from 2.85 ± 0.015 with a coefficients of variation of 0.5% to 2.81 ± 0.036 with a coefficients of variation of 1.3% across devices.

“
Conclusion · 1 of 2

The study results demonstrated consistent stiffness values for both lenses and corneas within and between the three BOSS devices tested.

Conclusion · 2 of 2

The study shows that this device could be a useful new biomechanics-measuring tool for applications in ophthalmology.

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