Post

Rita Ehrlich
Experimental eye research
10y
Animal / preclinicalExperimental eye research · 2016

Bevacizumab clearance through the iridocorneal angle following intravitreal injection in a rat model.

Orly Gal-Or, Assaf Dotan, Mor Dachbash … Tami Livnat
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OphthalmologyAnimal / preclinical

Bevacizumab was no longer detected in eye drainage channels 48 h after injection.

Bevacizumab clearance through the iridocorneal angle following intravitreal injection in a rat model.

Orly Gal-Or … Tami Livnat
Experimental eye research · 2016
Background

Antivascular endothelial growth factor (antivascular endothelial growth factor) agents have been widely used for a variety of ocular disorders.

48
Results
48
h
no drug staining detected in the eye’s fluid-drainage channels
More results

The etiology of sustained ocular hypertension following intravitreal administration of anti-VEGF agents is yet to be unraveled.

Bevacizumab (25 mg/ml) was injected intravitreally after 3 days.

Donkey anti-human IgG labeled with Alexa Fluor(®) 488 was used for bevacizumab immunoreactivity detection.

More results

Anti-CD31 antibody was used as a marker for Schlemm's canal endothelial cells.

“
Conclusion

Bevacizumab molecules passed through the aqueous outflow channels within 48 h after intravitreal bevacizumab injection.

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