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Rita Ehrlich
European journal of ophthalmology
17y
Randomized trialEuropean journal of ophthalmology · 2009

Visual function, optic nerve structure, and ocular blood flow parameters after 1 year of glaucoma treatment with fixed combinations.

Ingrida Januleviciene, Rita Ehrlich, Brent Siesky … Alon Harris
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OphthalmologyRandomized trial

Latanoprost/timolol lowered intraocular pressure by 5.44 mmHg after 12 months.

Visual function, optic nerve structure, and ocular blood flow parameters after 1 year of glaucoma treatment with fixed combinations.

Ingrida Januleviciene … Alon Harris
European journal of ophthalmology · 2009
Purpose

To compare the effects of latanoprost/timolol (LTFC) versus dorzolamide/timolol (DTFC) fixed combinations on intraocular pressure (IOP), visual function, and retrobulbar blood flow in patients with open-angle glaucoma (open-angle glaucoma).

Methods

This was a prospective, randomized, double masked, parallel study on 30 patients with open-angle glaucoma.

n = 30 patients
Results

lower pressure measured inside the eye after 12 months

DTFC cohort
5mmHg
LTFC cohort
5.44mmHg
More results

No statistically significant differences in visual field or nerve fiber layer thickness were observed between the treatment groups during 12 months of therapy.

Mean increase over 1 year of treatment in ocular perfusion and diastolic perfusion pressures were 10.46% and 10.67% in the DTFC group and 7.47% and 5.61% in the LTFC group, respectively.

More results

Ophthalmic artery resistive index (resistive index) and short posterior ciliary artery resistive index were significantly different at the 12 months visit between the two treatment groups (p=0.05 and p=0.000, respectively): DTFC treatment showed decrease in the resistive index.

“
Conclusion

One year of treatment with LTFC or DTFC resulted in similar IOP lowering effects as well as stable visual function and structure. The DTFC group showed lower vascular resistance in retrobulbar vessels compared to the LTFC group.

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