Sarcoidosis data-driven patient trajectories and predictors of chronic disease.

Among 9665 patients, two distinct trajectories were identified: a resolving trajectory (71.5%) with near-complete remission of sarcoidosis-related visits within two years, and a chronic trajectory (28.5%) with persistently elevated visit rates over five years.

Older age modestly increased the risk of chronic disease.

In the Karolinska cohort, Löfgren's syndrome and HLA-DRB1*03 were strongly associated to a resolving course.

Chronic sarcoidosis was associated with higher risks of infection, heart failure, diabetes, depression, anxiety, and early death.