Current Recommendations, Antibiotic Resistance, and Emerging Treatments for Gram-Positive Ocular Infections…

ReviewAntibiotics (Basel, Switzerland)· Jul 2026

Current Recommendations, Antibiotic Resistance, and Emerging Treatments for Gram-Positive Ocular Infections in the United States.

Inès Fenniri, Camille André

CorneaReviewTreatmentQ1IF 5.8

Nearly half of intraocular Staphylococcus aureus in United States surveillance was methicillin-resistant

Current Recommendations, Antibiotic Resistance, and Emerging Treatments for Gram-Positive Ocular Infections in the United States.

Inès Fenniri, Camille André

Antibiotics (Basel, Switzerland) · Jul 2026

Background

Severe bacterial keratitis and endophthalmitis are leading causes of corneal scarring, enucleation, and permanent vision loss, and are increasingly complicated by multidrug-resistant Gram-positive ocular pathogens.

45.9%

Results

45.9%

Share of eye-infection Staphylococcus aureus samples resistant to methicillin-type antibiotics, 2009-2020

More results

While new antibiotics have been approved for systemic infections, vancomycin remains the standard of care for severe Gram-positive ocular infections.

“

Conclusion

This review details the current antimicrobial recommendations for the most frequent ocular infections, followed by the epidemiology and molecular mechanisms of resistance in S. aureus , coagulase-negative staphylococci, and S. pneumoniae .

Current Recommendations, Antibiotic Resistance, and Emerging Treatments for Gram-Positive Ocular Infections in the United States.

Current Recommendations, Antibiotic Resistance, and Emerging Treatments for Gram-Positive Ocular Infections in the United States.

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