Renal Impairment and Age-related Macular Degeneration: A Comprehensive Systematic Review and Meta-Analysis.

Cross-sectionalAmerican journal of ophthalmology· Jul 2026

Renal Impairment and Age-related Macular Degeneration: A Comprehensive Systematic Review and Meta-Analysis.

Anas Alamoudi, Ahmed Alnabihi, Naif Almufarriji … Mohammed Abdulkarem

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RetinaCross-sectionalPrognosisQ1IF 4.2

Chronic kidney disease is associated with higher odds of age-related macular degeneration

Renal Impairment and Age-related Macular Degeneration: A Comprehensive Systematic Review and Meta-Analysis.

Anas Alamoudi … Mohammed Abdulkarem

American journal of ophthalmology · Jul 2026 · Q1 in Ophthalmology

Background

TOPIC: Chronic kidney disease (chronic kidney disease) and age-related macular degeneration (AMD) share vascular and inflammatory pathways.

Methods

We systematically searched MEDLINE, Embase, Scopus, and Web of Science from inception to 11 August 2025.

Results

people with long-term kidney disease more often had this eye-ageing condition

OR 1.27 (95% CI 1.07 to 1.50)

null 1

1.07

1.50

CI excludes the null - significant

More results

Effects were similar by design (P for subgroup difference = 0.84): cohorts OR = 1.29 (0.98-1.69) and cross-sectional studies OR = 1.25 (0.96-1.62).

More results

By phenotype, associations were significant for non-exudative AMD (OR = 1.46, 1.06-1.99), while exudative AMD showed an imprecise increase (OR = 1.71, 0.72-4.08), and early AMD was not statistically significant (OR = 1.32, 0.90-1.93).

“

Conclusion

Renal impairment, particularly reduced eGFR (<60 mL/min/1.73 m²), elevated serum creatinine, and dialysis exposure, was associated with modestly higher odds of AMD, and the association was most consistent for non-exudative disease.

Renal Impairment and Age-related Macular Degeneration: A Comprehensive Systematic Review and Meta-Analysis.

Renal Impairment and Age-related Macular Degeneration: A Comprehensive Systematic Review and Meta-Analysis.

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