Post

New research · Ophthalmology
American journal of ophthalmology · 1w
Cross-sectionalAmerican journal of ophthalmology · 2026

Renal Impairment and Age-related Macular Degeneration: A Comprehensive Systematic Review and Meta-Analysis.

Anas Alamoudi, Ahmed Alnabihi, Naif Almufarriji … Mohammed Abdulkarem
Read paper
OphthalmologyCross-sectional

Chronic kidney disease is associated with higher odds of age-related macular degeneration

Renal Impairment and Age-related Macular Degeneration: A Comprehensive Systematic Review and Meta-Analysis.

Anas Alamoudi … Mohammed Abdulkarem
American journal of ophthalmology · 2026
Background

TOPIC: Chronic kidney disease (chronic kidney disease) and age-related macular degeneration (AMD) share vascular and inflammatory pathways.

Methods

We systematically searched MEDLINE, Embase, Scopus, and Web of Science from inception to 11 August 2025.

Results

people with long-term kidney disease more often had this eye-ageing condition

OR 1.27 (95% CI 1.07 to 1.50)
null 1
1.07
1.50
CI excludes the null - significant
More results

Effects were similar by design (P for subgroup difference = 0.84): cohorts OR = 1.29 (0.98-1.69) and cross-sectional studies OR = 1.25 (0.96-1.62).

More results

By phenotype, associations were significant for non-exudative AMD (OR = 1.46, 1.06-1.99), while exudative AMD showed an imprecise increase (OR = 1.71, 0.72-4.08), and early AMD was not statistically significant (OR = 1.32, 0.90-1.93).

“
Conclusion

Renal impairment, particularly reduced eGFR (<60 mL/min/1.73 m²), elevated serum creatinine, and dialysis exposure, was associated with modestly higher odds of AMD, and the association was most consistent for non-exudative disease.

Read paper
0 comments

No comments yet. Be the first.

Related papers

LatestFoundational
Cross-sectional
44.1%
had too much homocysteine in the blood, a far larger share than in dry AMD or healthy eyes
Cohort Study
92.3%
most laser-treated eyes had a favorable eye-structure outcome
Cohort Study
56%
lost three or more lines on the eye-chart vision test
Cohort Study
50%
older patients were more likely to lose three or more lines of vision
Study
81%
trials where mask air leaks were detected blowing toward the eyes
Cohort Study
13.5%
Central retinal artery peak blood-flow speed was 13.5% lower in diabetic patients.
Study
379 +/- 156 microm
lower thickness in the central retina, checked with an eye scan
Case Report
9 of 10 eyes
eyes had better measured vision after treatment