Post

New research · Oncology
Medical sciences (Basel, Switzerland) · 1w
Cohort studyMedical sciences (Basel, Switzerland) · 2026

Cancer Risk in Clinically Recognized Celiac Disease: A Nationwide Propensity-Matched Cohort Study.

Reem Zabit, Ahmad Shibly, Jamal Zidan … Ismaell Massalha
Read paper
OncologyCohort study

Clinically recognized celiac disease is associated with a higher rate of invasive cancer

Cancer Risk in Clinically Recognized Celiac Disease: A Nationwide Propensity-Matched Cohort Study.

Reem Zabit … Ismaell Massalha
Medical sciences (Basel, Switzerland) · 2026
Background

Celiac disease (celiac disease) is common, but its cancer-risk profile remains incompletely defined.

Methods

We used longitudinal electronic health record (electronic health record) data from Clalit Health Services for a propensity-matched cohort.

n = 8143 individuals
Results

people with celiac disease developed invasive cancer more often than matched people without it

HR 1.68 (95% CI 1.31 to 2.14)
null 1
1.31
2.14
CI excludes the null - significant
More results

The primary matched cohort included 8143 individuals: 1006 with celiac disease and 7137 controls, contributing 49,330.5 person-years.

Strongest signals were hematological malignancy codes (HR 1.99), lymphoma codes (HR 1.90), and gastrointestinal (gastrointestinal) cancer codes (HR 2.71).

More results

Associations persisted after one-year and two-year lags.

In the dated-event sensitivity cohort (161 celiac disease; 1610 controls), celiac disease remained associated with invasive cancer (HR 1.68, 95% CI 1.31-2.14), with the strongest signals for lymphoma (HR 2.81) and gastrointestinal cancer (HR 2.25).

“
Conclusion · 1 of 2

In clinically recognized celiac disease, cancer hazard was elevated and category-specific, concentrated in hematological, lymphoid, and gastrointestinal codes with a gut-oriented T-cell lymphoma signal.

Conclusion · 2 of 2

The findings support targeted clinical vigilance, not expanded screening, and describe relative associations that require registry-linked confirmation.

Read paper
0 comments

No comments yet. Be the first.

Related papers

LatestFoundational
AI / Informatics
0.861
the combined model's improved ability to correctly diagnose liver cancer
Guideline
50 and 70 years of age
Australians within this age range are eligible for lung cancer screening
Review
80%
experts agreed on most questions about managing second breast cancer events
Guideline
“As more new targeted agents become available and hypomethylating agent-based triplet combinations are used more widely, we fully anticipate that we will, in some years' time, write a fourth guideline on the management of AML in older patients.”
Cohort Study
3.8-fold
Sickle cell disease recipients had 3.8-fold higher odds of DNA Damage Response-mutant clonal hematopoiesis.
Cross-sectional
1.3%
very few hospitals had a dedicated joint heart-and-cancer specialist team, despite broad support
Study
0.02
Average distance error of 0.02 mm between computed and physically measured locations
AI / Informatics
42
Number of individual research projects meeting eligibility and analyzed in this review