Hyperhomocysteinemia was more common in neovascular age-related macular degeneration than in dry disease or controls
Association of neovascular age-related macular degeneration and hyperhomocysteinemia.
Ruth Axer-Siegel … Ben-Ami Sela
American journal of ophthalmology · Jan 2004 · Q1 in Ophthalmology
Purpose
To assess the relationship between plasma homocysteine levels and exudative neovascular age-related macular degeneration (AMD).
Methods
Were compared for plasma homocysteine levels with 58 patients who had dry AMD (24 male, 34 female) with a mean age of 76.3 years (SD = 8.4) and with a control group of 56 age-matched subjects (27 male, 29 female), with a mean age of 77.3 years (SD = 8.2).
n = 59 patients
Results
had too much homocysteine in the blood, a far larger share than in dry AMD or healthy eyes
44.1%
Neovascular AMD
22.4%
Dry AMD
21.4%
Control
More results
Homocysteine levels were higher by 27.9% in the neovascular AMD than in the dry AMD group, and by 21.9% than in the control group (P <.02).
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Conclusion
This study suggests an association between an elevated plasma level of homocysteine and exudative neovascular AMD but not dry AMD.
