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New research · Infectious Disease
Ocular immunology and inflammation · 3h
Meta-analysisOcular immunology and inflammation · 2026

Epidemiological Characterization of Uveitis in Pediatric Population: A Systematic Review and Meta Analysis.

Tom Liba, Amit Olami, Michael Brant … Yael Sharon
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Infectious DiseaseMeta-analysis

Idiopathic uveitis is the most common diagnosis in children with uveitis.

Epidemiological Characterization of Uveitis in Pediatric Population: A Systematic Review and Meta Analysis.

Tom Liba et al. · Ocular immunology and inflammation · 2026
Background

Pediatric uveitis is a leading cause of visual impairment, often resulting in severe complications without timely and appropriate intervention.

Purpose

To identify prevalent causes of pediatric uveitis, assess geographic variations, and evaluate demographic patterns.

Methods

Retrospective cohort and cross-sectional studies reporting pediatric uveitis etiology were included.

39.71%
Results
this is the percentage of children with eye inflammation whose cause is unknown
More results

Data were pooled using a random-effects model, with heterogeneity assessed via I 2 statistics.

Out of a total of 8,974 studies initially considered, only 30 met the criteria for inclusion.

More results

Juvenile idiopathic arthritis (JIA)-associated uveitis was most prevalent (15.59%, 95% CI: 11.92-20.14%) of all cases and was the leading defined non-infectious cause, Behçet's disease (4.8%) and Vogt-Koyanagi-Harada disease (3.63%) of all cases.

“
Conclusion

Standardizing diagnostic criteria can help reduce the burden of pediatric uveitis worldwide.

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