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New research · Nephrology
International urology and nephrology · 16h
Cohort studyInternational urology and nephrology · 2026

Persistent kidney dysfunction after leptospirosis-associated acute kidney injury: a case series from coastal Karnataka, India.

Astha Sethi, Attur Ravindra Prabhu, V Shashidhar, Nitin Gupta
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NephrologyCohort study

14% of leptospirosis acute kidney injury survivors had chronic kidney disease at three months

Persistent kidney dysfunction after leptospirosis-associated acute kidney injury: a case series from coastal Karnataka, India.

Astha Sethi et al. · International urology and nephrology · 2026
Background

Leptospirosis has been infrequently associated with persistent kidney dysfunction fulfilling the criteria for chronic kidney disease (CKD).

Purpose

This study aimed to describe the clinical profile, laboratory findings, treatment requirements, and kidney outcomes of patients without recognised CKD risk factors who had persistent kidney dysfunction fulfilling CKD criteria at three-month follow-up after leptospirosis-associated Acute Kidney Injury (AKI).

Methods

With leptospirosis-associated AKI who fulfilled Kidney Disease: Improving Global Outcomes (KDIGO) criteria for CKD at three-month follow-up were included.

n = 101 hospitalised patients
14.0%
Results
About 1 in 7 survivors without prior risk factors had persistent kidney damage
n = 101 hospitalised patients
More results

Among 101 hospitalised patients with leptospirosis, 67 (66.3%) developed AKI.

Of these, 7 (10.4%) died in hospital, and 17 (28.3%) of the 60 survivors did not undergo serum creatinine testing at three-month follow-up.

More results

Jaundice was present in 4/6, 66.7%, of patients, leukocytosis was observed in all patients, and thrombocytopenia was present in all patients.

Myocarditis was noted in 2/6, 33.3%, of patients.

“
Conclusion · 1 of 2

Severe leptospirosis-associated AKI may be followed by persistent kidney dysfunction at three months despite improvement in serum creatinine from peak values.

Conclusion · 2 of 2

Persistent creatinine elevation at discharge may be an important clinical warning sign.

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