Higher triglyceride levels associated with greater odds of prostate cancer
Lipid biomarkers of prostate cancer: insights from triglycerides and saturated fatty acid metabolism.
Jia Wei He et al. · Future oncology (London, England) · 2026
Background
Prostate cancer poses a substantial threat to men's health.
Methods
A multicenter case-control study was executed.
Results
Higher triglycerides linked to higher odds of prostate cancer (odds, not risk)
OR by subgroup · 95% CI
More results
Both indicators were positively correlated with continuous Gleason score (triglyceride: β = 0.710, OR = 2.89,95% CI: 1.96-4.26, p < 0.001; saturated fatty acid/fatty acid: β = 0.645, OR = 2.57,95% CI: 1.78-3.71, p < 0.001), and were significantly elevated in prostate cancer tissues compared with adjacent non-cancerous tissues.
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Conclusion
This study confirms the importance of triglycerides and saturated fatty acid/fatty acid ratio in prostate cancer progression, which could be used for diagnosis and prognosis. Reducing their levels may help prevent prostate cancer.