Diagnostic Performance of Radial EBUS-Guided Cryobiopsy for Peripheral Lung Lesions: First Experience in…

Cohort studyThe clinical respiratory journal· Jul 2026

Diagnostic Performance of Radial EBUS-Guided Cryobiopsy for Peripheral Lung Lesions: First Experience in Morocco.

Lamya Chrif Morand, Khalid Bouti, Imane Saidi … Anis Rafik

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Pulmonology & Critical CareCohort studyDiagnosisQ2IF 2.1

Radial endobronchial ultrasound-guided cryobiopsy achieved a definitive diagnosis in 75.3% of peripheral lung lesions

Diagnostic Performance of Radial EBUS-Guided Cryobiopsy for Peripheral Lung Lesions: First Experience in Morocco.

Lamya Chrif Morand … Anis Rafik

The clinical respiratory journal · Jul 2026

Background

Accurate diagnosis of peripheral pulmonary lesions (peripheral pulmonary lesions) remains challenging.

Purpose

This study evaluated the diagnostic yield and safety of radial endobronchial ultrasound (r-EBUS)-guided transbronchial cryobiopsy using a 1.1-mm cryoprobe.

Methods

Were performed under general anesthesia using a laryngeal mask airway, a flexible bronchoscope, r-EBUS for localization, and a 1.1-mm cryoprobe inserted through a guide sheath.

n = 73 patients

75.3%

Results

75.3%

definitive diagnosis reached in most peripheral lung growths sampled by this freeze-biopsy method

n = 73 patients

More results

Mean lesion diameter was 21 mm, with 79.5% of patients exhibiting a positive bronchus sign.

Malignancies accounted for 60.3% of diagnoses, whereas benign etiologies, including tuberculosis, represented 15.1%.

Bleeding occurred in 19.2% of cases; all events were mild and managed with the balloon blocker.

More results

Pneumothorax occurred in six patients (8.2%), with four requiring chest tube drainage.

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Conclusion · 1 of 2

r-EBUS-guided transbronchial cryobiopsy using a 1.1-mm cryoprobe is feasible and effective for diagnosing peripheral pulmonary lesions, with a diagnostic yield of 75.3%.

Conclusion · 2 of 2

Protocolized use of a balloon blocker effectively prevents severe hemorrhagic complications. Pneumothorax risk warrants vigilance, particularly in patients with infectious cavitary disease.

Diagnostic Performance of Radial EBUS-Guided Cryobiopsy for Peripheral Lung Lesions: First Experience in Morocco.

Diagnostic Performance of Radial EBUS-Guided Cryobiopsy for Peripheral Lung Lesions: First Experience in Morocco.

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