Post

New research · Ophthalmology
Ophthalmology · 22h
ReviewOphthalmology · 2026

Effectiveness of Corticosteroid-Sparing Topical Treatments for Vernal Keratoconjunctivitis in Children: A Report by the American Academy of Ophthalmology.

Kara M Cavuoto, Julius T Oatts, Sudha Nallasamy … Melinda Y Chang
Read paper
OphthalmologyReview

Most high-quality studies support calcineurin inhibitors for vernal keratoconjunctivitis in children.

Effectiveness of Corticosteroid-Sparing Topical Treatments for Vernal Keratoconjunctivitis in Children: A Report by the American Academy of Ophthalmology.

Kara M Cavuoto et al. · Ophthalmology · 2026
Purpose

To review the published literature assessing the efficacy of corticosteroid-sparing topical treatments for vernal keratoconjunctivitis (VKC) in children 18 years of age and younger.

Methods

Fifteen articles met the inclusion criteria and were assigned a level of evidence rating by the panel methodologist.

n = 9 studies
4/6
Results
Four of six high-quality studies found cyclosporine or tacrolimus improved symptoms.
n = 9 studies
More results

Six studies were rated level I, and 9 studies were rated level III.

Most level III evidence studies (5/9) reported outcomes using tacrolimus drops or ointment.

Apart from application site discomfort, the studies reported no significant adverse events.

“
Conclusion · 1 of 2

Level I and III evidence demonstrate that treatment with corticosteroid-sparing topical interventions such as cyclosporine, tacrolimus, sodium cromoglycate, and interferon alpha-2b can improve clinical signs and symptoms of VKC in children.

Conclusion · 2 of 2

Most of the level I evidence supports the use of the calcineurin inhibitors-cyclosporine and tacrolimus. FINANCIAL DISCLOSURE(S): Proprietary or commercial disclosure may be found after the references.

Read paper
0 comments

No comments yet. Be the first.

Related papers

LatestFoundational
Cohort Study
median 9
optometry referrals contained more complete documentation for glaucoma
Study
71.27%
medical students' higher accuracy in identifying eye infections after artificial intelligence training
Cross-sectional
64%
most patients reported little difficulty with their eye injections
Cross-sectional
37%
Only 37% of primary care providers and endocrinologists correctly identified diabetic retinopathy status.
Randomized Trial
adjusted difference -4.97
Baduanjin exercise led to a better overall quality of life than routine care
Study
58.26%
Qwen-7B correctly found eye diseases in over half of cases without specific training
Case Report
24 months
the patient's eye cancer remained gone for this period after treatment
Study
Mean 184 vs. 137
Residents in subsidized programs performed more cataract surgeries as primary surgeon.