A Universal Bio-Hybrid Nanoparticle Backpack Platform Endows Stem Cells with Microenvironmental Resilience and Sustained Paracrine Signaling.

The therapeutic potential of mesenchymal stem cells (mesenchymal stem cells) in regenerative medicine is frequently thwarted by hostile post-injury microenvironments characterized by oxidative stress, inflammation, and rapid clearance, which compromise cell survival and paracrine efficacy.

Using corneal chemical injury as a rigorous proof-of-concept model, this platform demonstrated unprecedented regenerative potency.