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New research · Ophthalmology
Reports of practical oncology and radiotherapy : journal of Greatpoland Cancer Center in Poznan and Polish Society of Radiation Oncology · 22h
Case reportReports of practical oncology and radiotherapy : journal of Greatpoland Cancer Center in Poznan and Polish Society of Radiation Oncology · 2026

Salvage ultra-low-dose radiotherapy for conjunctival mantle cell lymphoma - a case report and literature review.

Suyapa Margarita Meléndez Varela, Concepción Victoria Fernández, Sergio Manuel Melgar Rivera … Luis Cascallar Caneda
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OphthalmologyCase report

Ultra-low-dose radiotherapy was associated with maintained orbital remission in one patient.

Salvage ultra-low-dose radiotherapy for conjunctival mantle cell lymphoma - a case report and literature review.

Suyapa Margarita Meléndez Varela et al. · Reports of practical oncology and radiotherapy : journal of Greatpoland Cancer Center in Poznan and Polish Society of Radiation Oncology · 2026
Background

Mantle cell lymphoma (MCL) is an aggressive B-cell non-Hodgkin lymphoma with variable responses to frontline chemotherapy.

Results
months
the patient's eye cancer remained gone for this period after treatment
More results

Orbital involvement is rare, and data on radiotherapy, particularly at ultra-low doses, remain limited.

The authors report a 64-year-old male with conjunctival MCL refractory to a single cycle of R-CHOP (rituximab, cyclophosphamide, doxorubicin, vincristine and prednisone).

More results

He underwent salvage ultra-low-dose radiotherapy (VLDRT; 4 Gy in 2 fractions) to the left orbit using volumetric modulated arc therapy (VMAT) with 6 MV photons, daily cone beam computed tomography (CBCT) image guidance, thermoplastic mask immobilization, and a 0.5 cm bolus.

“
Conclusion

This case, together with recent literature, highlights the potential role of VLDRT as a salvage strategy in aggressive lymphomas.

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