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New research · Ophthalmology
Journal of contemporary brachytherapy · 23h
Cohort studyJournal of contemporary brachytherapy · 2026

Ruthenium-106 ocular surface brachytherapy for incompletely excised conjunctival melanoma and squamous cell carcinoma.

Efstathios T Detorakis, Georgia Solomou, Maria Detoraki, Kostas Perisinakis
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OphthalmologyCohort study

Ruthenium-106 brachytherapy was associated with a 75% local tumor control rate for incompletely excised conjunctival malignancies.

Ruthenium-106 ocular surface brachytherapy for incompletely excised conjunctival melanoma and squamous cell carcinoma.

Efstathios T Detorakis et al. · Journal of contemporary brachytherapy · 2026
Purpose

To examine the efficacy and safety of ruthenium-106 ( 106 Ru) ocular surface brachytherapy for incompletely excised conjunctival melanoma (CM) and conjunctival squamous cell carcinoma (CSCC) patients, with no adjunctive treatments applied to the primary tumor beds treated with 106 Ru brachytherapy.

Methods

A retrospective analysis of a consecutive cohort of eight patients (four with CM and four with CSCC), treated at the Department of Ophthalmology of the University Hospital of Heraklion, was performed.

Results
75% of patients had their conjunctival melanoma or squamous cell carcinoma controlled locally.
More results

In two patients (one CM and one CSCC), orbital exenteration was required due to orbital invasion.

Both cases involved neglected and extensive lesions, suggesting possible pre-existing microscopic deeper infiltration.

No radiation-related ocular surface toxicity was observed.

“
Conclusion · 1 of 2

In line with previous reports, these findings highlight the role of ocular surface brachytherapy in the management of incompletely excised conjunctival malignancies.

Conclusion · 2 of 2

Ruthenium-106 surface brachytherapy may represent an effective sole adjunctive treatment option for selected cases of CM and CSCC, even when using plaques designed for intra-ocular applications, such as CCB (BEBIG) plaque.

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