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New research · Rheumatology
Clinical nutrition ESPEN · 23h
Cohort studyClinical nutrition ESPEN · 2026

Prevalence, Incidence and Prognostic Impact of GLIM-Defined Malnutrition in Systemic Sclerosis: A Longitudinal Cohort Study.

Bochao Jiang, Seyed Ehsan Saffari, Maria Noviani … Ennaliza Salazar
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RheumatologyCohort study

Malnutrition is associated with a higher mortality rate in patients with systemic sclerosis.

Prevalence, Incidence and Prognostic Impact of GLIM-Defined Malnutrition in Systemic Sclerosis: A Longitudinal Cohort Study.

Bochao Jiang et al. · Clinical nutrition ESPEN · 2026
Background

Malnutrition is a known complication in systemic sclerosis (SSc), yet longitudinal data using standardised diagnostic criteria in Asian populations are limited.

Purpose

We aimed to determine the prevalence and incidence of malnutrition, identify risk factors for its development and evaluate its association with mortality in the SSc cohort using the Global Leadership Initiative on Malnutrition (GLIM) criteria.

Methods

Were included if they had at least one baseline assessment and ≥6 months of follow-up.

n = 341 patients
Results

malnutrition is associated with a higher rate of death in people with systemic sclerosis

HR by subgroup · 95% CI
null = 1
increasing age [
1.04
04
0.99
99
2.76
More results

Among 341 patients with SSc, baseline malnutrition was 14.4%, with an incidence rate of 16.83 per 1000 person-years.

No baseline clinical variables were significantly associated with the development of malnutrition.

“
Conclusion · 1 of 2

Despite a relatively low incidence, GLIM-defined malnutrition had a strong independent association with mortality in SSc.

Conclusion · 2 of 2

These findings are of prognostic value and support the integration of routine screening and standardized malnutrition diagnosis in SSc care in Asian populations.

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