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New research · Surgery
Eye (London, England) · 1d
Cohort studyEye (London, England) · 2026

Outcomes of phacoemulsification combined with ab interno trabeculotomy: stratified by incision extent, glaucoma severity, and baseline number of medications.

Takashi Nishida, Takuhei Shoji, Masaki Tanito
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SurgeryCohort study

Phacoemulsification with TMH trabeculotomy had a 59.0% two-year cumulative success rate.

Outcomes of phacoemulsification combined with ab interno trabeculotomy: stratified by incision extent, glaucoma severity, and baseline number of medications.

Takashi Nishida et al. · Eye (London, England) · 2026
Purpose

To evaluate outcomes of phacoemulsification plus Tanito microhook (TMH) trabeculotomy and assess differences by incision extent, glaucoma severity, and baseline medications classes.

Methods

Retrospective cohort of 880 open-angle glaucoma eyes (119 exfoliation glaucoma, 761 primary open-angle glaucoma) undergoing phaco-TMH.

n = 880 open-angle glaucoma eyes
Results

Over two years, 59.0% of patients achieved lower eye pressure or fewer medications.

HR 1.14 (95% CI 0.85 to 1.53)
null = 10.851.53
CI crosses the null - not significant
More results

Mean (SD) IOP decreased from 17.2 (4.9) mmHg at baseline to 13.1 (3.5) at 12 months and 13.1 (3.9) at 24 months, and medications decreased from 2.6 (1.3) to 2.0 (1.3) at 12 and 24 months.

In the multivariable Cox model, ≥6 clock hours was not significantly associated with surgical failure compared with <6 clock hours (adjusted HR, 1.14; 95% CI, 0.85 to 1.53; P = 0.367).

More results

Higher baseline medication burden was associated with worse success across IOP-defined criteria.

“
Conclusion · 1 of 2

In patients undergoing phacoemulsification combined with TMH trabeculotomy, IOP and medication burden improved through 2 years.

Conclusion · 2 of 2

Surgical success did not differ by incision extent or baseline glaucoma severity, whereas higher baseline medication burden was associated with worse IOP-defined success.

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