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New research · Pulmonology & Critical Care
Inflammatory bowel diseases · 23h
Cohort studyInflammatory bowel diseases · 2026

Increased risk of respiratory syncytial virus infection in patients with active inflammatory bowel disease: a matched cohort study.

Mohamed H Eldesouki, Youssef Hafez, Ahmed E Salem … Francis A Farraye
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Pulmonology & Critical CareCohort study

Active inflammatory bowel disease is associated with higher odds of respiratory syncytial virus infection.

Increased risk of respiratory syncytial virus infection in patients with active inflammatory bowel disease: a matched cohort study.

Mohamed H Eldesouki et al. · Inflammatory bowel diseases · 2026
Background

Immune dysregulation, immunosuppressive therapy and active inflammatory bowel disease (IBD) increase susceptibility to respiratory syncytial virus (RSV) infection.

Methods

Using the TriNetX Analytics Network from October 2024 through March 2025, we identified adult patients (aged ≥18 years) with IBD.

n = 2879 patients
Results

patients with active inflammatory bowel disease had higher odds of respiratory syncytial virus infection

aOR 1.55 (95% CI 1.18 to 2.04)
null 1
1.18
2.04
CI excludes the null - significant
More results

Among 141 763 patients (47 883 patients with active IBD, 93 880 patients with nonactive IBD), 2879 patients with active IBD and 3583 with nonactive IBD received the RSV vaccination.

After matching, each cohort included 46 308 patients.

RSV risk remained higher among patients with active IBD both with and without systemic corticosteroid exposure.

More results

Among RSV-vaccinated patients, RSV infection rates were not significantly different between active and nonactive IBD (aOR, 1.26; 95% CI, 0.78-1.79).

“
Conclusion · 1 of 2

Patients with active IBD had higher risk of RSV infection. Increased RSV risk was observed both among patients with active IBD with and without systemic corticosteroid exposure.

Conclusion · 2 of 2

Among RSV-vaccinated patients, RSV infection rates were not significantly different between active and nonactive IBD. Further prospective studies are needed to validate these findings.

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