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New research · Gastroenterology
JAMA · 23h
ReviewJAMA · 2026

Gastroparesis: A Review.

Michael Camilleri
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GastroenterologyReview

Gastroparesis affects 21.5 per 100 000 persons in the US.

Gastroparesis: A Review.

Michael Camilleri · JAMA · 2026
Background

IMPORTANCE: Gastroparesis is a condition of delayed gastric emptying in the absence of gastric outlet obstruction.

21.5
Results
per 100 000 persons
This is the number of US people with confirmed slow stomach emptying
More results

OBSERVATIONS: Gastroparesis, which is caused by reduced contractions of the distal stomach or abnormal pyloric relaxation, is more common among females than males (ratio, 2:1-4:1) and typically causes nausea, vomiting, early satiety, bloating, and abdominal pain or discomfort.

More results

In a large US epidemiological study involving 82.6 million patients, the most common causes of gastroparesis were type 2 diabetes (51.7%), postsurgical effects (15%), medication-induced (11.8%), idiopathic (11.3%), type 1 diabetes (5.7%), and other (4.5%).

“
Conclusion · 1 of 2

Gastroparesis is a condition of delayed gastric emptying without gastric outlet obstruction that is diagnosed based on a gastric emptying study. First-line treatments include a small particle diet and antiemetics and prokinetics.

Conclusion · 2 of 2

Severe refractory gastroparesis may be treated with procedures such as G-POEM or gastric electrical simulation.

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