Post

New research · Anesthesiology
Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia · 1d
Randomized trialJournal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia · 2026

Effect of ketofol versus Fentanyl-Midazolam sedation on neurological recovery in traumatic brain Injury: A randomised study.

Umadevi Manyam, Navdeep Sokhal, Suman Sokhal … Vinay Chitturi
Read paper
AnesthesiologyRandomized trial

Ketofol sedation is associated with higher odds of good neurological recovery at 30 days.

Effect of ketofol versus Fentanyl-Midazolam sedation on neurological recovery in traumatic brain Injury: A randomised study.

Umadevi Manyam et al. · Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia · 2026
Background

Neurological recovery after traumatic brain injury (TBI) is multifactorial, and sedation is a cornerstone of neurocritical care because of its neuroprotective role.

Methods

This preliminary exploratory double-blind, randomised study compared ketofol (KP) with fentanyl-midazolam (FM) sedation in adults with moderate-to-severe TBI.

Results

ketofol sedation is linked to much higher chances of good brain recovery after 30 days

OR 3.63 (95% CI 1.11 to 11.85)
null = 11.1111.85
CI excludes the null - significant
More results

Although ketofol is widely used for anaesthesia, its effectiveness as a sedative regimen in the intensive care unit (ICU) has not been well studied.

The primary outcome was the Extended Glasgow Outcome Scale (GOSE) at 30 days.

More results

Secondary outcomes included GOSE at 90 days, incidence of propofol infusion syndrome (PRIS), duration of mechanical ventilation, haemodynamic stability, and ICU and hospital length of stay.

Baseline characteristics, including injury severity and Marshall CT scores, were comparable.

“
Conclusion

Ketofol-based sedation was safe and may be associated with improved early neurological recovery compared with fentanyl-midazolam, with a favourable trend toward improved long-term neurological recovery.

Read paper
0 comments

No comments yet. Be the first.

Related papers

LatestFoundational
Guideline
32 recommendations
recommendations for managing a serious blood clotting problem caused by a blood thinner
Study
250
median annual heart MRI scans for children's hearts performed per center
Randomized Trial
RR 0·88
Sugammadex led to a lower risk of lung problems or death after surgery
Cohort Study
OR = 1.036
higher body weight index slightly increases odds of thigh nerve pain after stomach surgery
Guideline
70 recommendations
experts agreed on guidelines for allergic reactions during or after surgery
Randomized Trial
9 vs. 5
patients felt much better comfort with hypnosis during bone marrow biopsy
Cohort Study
RR, 3.85
ST-depression, a specific heart signal, means a much higher risk of heart injury around surgery
Animal / Preclinical
6.7%
Only 6.7% of dogs experienced complications after uterine incision closure.