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Cohort studyEuropean journal of gastroenterology & hepatology · 2026

External validation of a prediction score for identifying a mild course of Crohn's disease.

Diogo Couto Sousa, Samuel Raimundo Fernandes, André Da Silva Neves … Luís Correia

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GastroenterologyCohort study

Patients with a low PreMiCC score had a higher rate of mild Crohn's disease.

External validation of a prediction score for identifying a mild course of Crohn's disease.

Diogo Couto Sousa et al. · European journal of gastroenterology & hepatology · 2026

Background

Crohn's disease has a heterogeneous course.

Methods

Were classified as having a score ≤2 or >2.

n = 342 patients

Results

Low PreMiCC score patients had a mild Crohn's disease course more often (42% vs 17%).

55%

Sensitivity

42%

Specificity

More results

At diagnosis, 55% had a PreMiCC score ≤2.

The PreMiCC score independently predicted biologic therapy [odds ratio = 1.65, 95% confidence interval (CI) = 1.33-2.04; P < 0.001].

Time to treatment escalation was shorter in patients with a score >2 (log-rank P < 0.001).

“

Conclusion

This first external validation confirms the predictive value of the PreMiCC score in a real-world cohort, supporting its use as a simple tool for early risk stratification in Crohn's disease.

Post

External validation of a prediction score for identifying a mild course of Crohn's disease.

Patients with a low PreMiCC score had a higher rate of mild Crohn's disease.

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