External validation of a prediction score for identifying a mild course of Crohn's disease.

At diagnosis, 55% had a PreMiCC score ≤2.

The PreMiCC score independently predicted biologic therapy [odds ratio = 1.65, 95% confidence interval (CI) = 1.33-2.04; P < 0.001].

Time to treatment escalation was shorter in patients with a score >2 (log-rank P < 0.001).