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New research · Dermatology
Journal of dermatological science · 1d
Cohort studyJournal of dermatological science · 2026

Imaging-guided tape stripping reveals consistent stratum corneum profiling of disease severity and treatment-responsive molecular features in pediatric atopic dermatitis.

Daniel Andersen, Oriol Yélamos, Marc Combalia … Susanne Brix
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DermatologyCohort study

Over 1100 genes are differentially expressed in atopic dermatitis skin compared to healthy skin.

Imaging-guided tape stripping reveals consistent stratum corneum profiling of disease severity and treatment-responsive molecular features in pediatric atopic dermatitis.

Daniel Andersen et al. · Journal of dermatological science · 2026
Background

Atopic dermatitis (AD) is a common pediatric skin disorder with early onset and complex pathophysiology.

Purpose

To evaluate the utility of imaging-guided tape stripping of SC, combined with transcriptomic and cytokine profiling, for characterizing molecular changes associated with disease severity and treatment response in pediatric AD.

Methods

By coupling real-time imaging-guided tape stripping with RNA sequencing and cytokine profiling, we examined SC molecular signatures in healthy children (n = 15) and lesional and non-lesional skin of pediatric AD patients (n = 39) with heterogeneous disease severity, both at baseline and following 2 weeks of topical corticosteroid treatment.

n = 15
> 1100 differentially expressed genes
Results
genes show different activity levels in atopic dermatitis skin compared to healthy skin
n = 15
More results

Lesional skin showed enrichment of type 17- and type 2-associated immune pathways, tissue remodeling, and cell cycle control.

Thirteen transcripts were significantly associated with clinical severity or itch, including CXCL8/IL8, CD300A, and FPR1.

More results

Most of these transcripts decreased after corticosteroid treatment, whereas CD300A and FCGR2B/CD32 remained elevated in a subset of children.

“
Conclusion

These findings support the use of real-time imaging-guided tape stripping as a standardized, minimally invasive approach for verifying SC sampling depth and monitoring molecular changes associated with disease activity and treatment response in pediatric AD.

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