Cost-Effectiveness and Budget Impact of Lung Cancer Screening: A Systematic Review.
Nuo Chen et al. · PharmacoEconomics · 2026
Background
Clinical trials have demonstrated the benefits of early detection of lung cancer (LC); however, the implementation of national LC screening programs remains under consideration.
Purpose
This systematic review aims to comprehensively synthesize the health economic evidence on LC screening and examine the methodological challenges.
Methods
We searched six databases from inception to July 31,2025.
More results
Ninety-five articles were identified, representing 93 full economic evaluations and nine BIAs.
Seventy-nine full economic evaluations supported the cost-effectiveness of LC screening, while five indicated it was not cost-effective.
Seventy studies evaluated low-dose computed tomography (LDCT) screening compared with no screening.
More results
All BIAs assessed an LDCT-based screening program.