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Randomized trialThe New England journal of medicine · 2026

Combined Oral Ivermectin and 5% Permethrin Cream to Treat Severe Scabies.

Charlotte Bernigaud, Giao Do-Pham, Elie Guichard … Olivier Chosidow

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DermatologyRandomized trial

Higher-dose ivermectin was not superior to standard dose for curing severe scabies.

Combined Oral Ivermectin and 5% Permethrin Cream to Treat Severe Scabies.

Charlotte Bernigaud et al. · The New England journal of medicine · 2026

Background

Severe scabies, a rare parasitic skin disease characterized by abundant skin mites, may be life-threatening and poses public health concerns worldwide.

Methods

We conducted a blinded randomized trial involving adults with severe scabies (i.e., profuse or crusted), as confirmed by parasitologic or dermoscopic assessment.

n = 132 patients

odds ratio for cure, 0.64

Results

higher-dose ivermectin meant lower odds of curing severe scabies

n = 132 patients

More results

No safety issues were identified.

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Conclusion · 1 of 2

Among adults, the 400-μg-per-kilogram dose of ivermectin plus 5% permethrin cream was not superior to the standard 200-μg-per-kilogram dose of ivermectin plus 5% permethrin cream in curing severe scabies.

Conclusion · 2 of 2

(Funded by the French Ministry of Health and French Society of Dermatology; ClinicalTrials.gov number, NCT02841215.).

Post

Combined Oral Ivermectin and 5% Permethrin Cream to Treat Severe Scabies.

Higher-dose ivermectin was not superior to standard dose for curing severe scabies.

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