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Randomized trialBoletin medico del Hospital Infantil de Mexico · 2026

Randomized controlled, double blind trial of use of vancomycin catheter-lock to prevent Gram-positive bloodstream infection in neonates.

Carlos López-Candiani, Silvestre García-de la Puente, José L Arredondo-García

PediatricsRandomized trial

Vancomycin catheter-lock diminished bloodstream infections by 25% in neonates.

Randomized controlled, double blind trial of use of vancomycin catheter-lock to prevent Gram-positive bloodstream infection in neonates.

Carlos López-Candiani et al. · Boletin medico del Hospital Infantil de Mexico · 2026

Background

Central lines are more frequently used in infant newborns; they offer advantages but are related to traumatic complications, obstruction and infection.

Purpose

The aim of this work was to evaluate the efficacy of vancomycin catheter lock to prevent Gram-positive bloodstream infection.

Methods

Randomized controlled doubled blind trial in newborn with central catheter in first 48 hours.

25%

Results

the reduction in bloodstream infections in babies with the vancomycin lock

More results

Mean stay of catheter was 14.6 days and parenteral nutrition 12 days.

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Conclusion

Vancomycin catheter-lock diminished bloodstream infections at 25% respect control group and 50% density infection per 1000 catheter/days, without being statistically significant.

Post

Randomized controlled, double blind trial of use of vancomycin catheter-lock to prevent Gram-positive bloodstream infection in neonates.

Vancomycin catheter-lock diminished bloodstream infections by 25% in neonates.

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