Prognostic impact of sepsis-induced coagulopathy on mortality and clinical outcomes in ICU patients.
Sepsis-induced coagulopathy is associated with over twice the odds of in-hospital mortality.
Prognostic impact of sepsis-induced coagulopathy on mortality and clinical outcomes in ICU patients.
This study aimed to assess the prognostic impact of sepsis-induced coagulopathy (sepsis-induced coagulopathy) on mortality and clinical outcomes in patients with sepsis admitted to the intensive care unit (intensive care unit).
This retrospective cohort study included 1,305 adult patients with sepsis admitted to a tertiary pulmonary intensive care unit between January 2016 and May 2025.
sepsis-related clotting issues are associated with over twice the odds of hospital death
The prevalence of sepsis-induced coagulopathy was 19.2%.
ROC analysis showed that the sepsis-induced coagulopathy score had moderate discriminative performance for predicting mortality (AUC: 0.619, 95% CI: 0.588-0.649, p < 0.001), with an sepsis-induced coagulopathy score ≥ 4 identified as the clinically interpreted threshold.
Sepsis-induced coagulopathy was independently associated with higher in-hospital mortality and greater need for vasopressor support in critically ill patients with sepsis.
These findings suggest that sepsis-induced coagulopathy may provide complementary prognostic information when interpreted alongside established severity assessment tools; however, prospective studies are needed to clarify its clinical relevance and potential role in patient management.