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Cohort studyBMC anesthesiology · 2026

Prognostic impact of sepsis-induced coagulopathy on mortality and clinical outcomes in ICU patients.

Ayşe Çapar, Derya Özyiğitoğlu, Cemre Abacı, Şeyma Başlılar

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Pulmonology & Critical CareCohort study

Sepsis-induced coagulopathy is associated with over twice the odds of in-hospital mortality.

Prognostic impact of sepsis-induced coagulopathy on mortality and clinical outcomes in ICU patients.

Ayşe Çapar et al. · BMC anesthesiology · 2026

Purpose

This study aimed to assess the prognostic impact of sepsis-induced coagulopathy (SIC) on mortality and clinical outcomes in patients with sepsis admitted to the intensive care unit (ICU).

Methods

This retrospective cohort study included 1,305 adult patients with sepsis admitted to a tertiary pulmonary ICU between January 2016 and May 2025.

n = 1,305 adult

Results

sepsis-related clotting issues are associated with over twice the odds of hospital death

OR by subgroup · 95% CI

More results

The prevalence of SIC was 19.2%.

ROC analysis showed that the SIC score had moderate discriminative performance for predicting mortality (AUC: 0.619, 95% CI: 0.588-0.649, p < 0.001), with an SIC score ≥ 4 identified as the clinically interpreted threshold.

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Conclusion · 1 of 2

SIC was independently associated with higher in-hospital mortality and greater need for vasopressor support in critically ill patients with sepsis.

Conclusion · 2 of 2

These findings suggest that SIC may provide complementary prognostic information when interpreted alongside established severity assessment tools; however, prospective studies are needed to clarify its clinical relevance and potential role in patient management.

Post

Prognostic impact of sepsis-induced coagulopathy on mortality and clinical outcomes in ICU patients.

Sepsis-induced coagulopathy is associated with over twice the odds of in-hospital mortality.

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