Risk of second primary malignancies after bladder cancer diagnosed at a young age: a SEER population-based…

Cohort studyInternational journal of clinical oncology· Jul 2026

Risk of second primary malignancies after bladder cancer diagnosed at a young age: a SEER population-based analysis.

Etan Eigner, Nicola Fazaa, Ameer Nsair … Kamil Malshy

Read paper

Bladder & Upper TractCohort studyPrognosisQ1IF 3.0

Young bladder cancer survivors have a higher risk of developing second primary malignancies.

Risk of second primary malignancies after bladder cancer diagnosed at a young age: a SEER population-based analysis.

Etan Eigner … Kamil Malshy

International journal of clinical oncology · Jul 2026 · Q1 in General Medicine

Background

Bladder cancer diagnosed at a young age is uncommon, but survivors often have long life expectancy, making long-term risks such as second primary malignancies (second primary malignancies) clinically relevant.

Purpose

We aimed to quantify the risk and distribution of second primary malignancies in this population.

Methods

Diagnosed with a first primary urothelial carcinoma of the bladder before age 50 were included.

n = 13,378 eligible patients

Results

young bladder cancer survivors have a higher risk of developing second cancers compared to the general population

SIR 1.67 (95% CI 1.58 to 1.76)

CI excludes the null - significant

More results

A total of 13,378 eligible patients contributed 140,014 person-years at risk to the second primary malignancies analysis.

During follow-up, 1,272 second primary malignancies were identified, excluding bladder and non-melanoma skin cancers, corresponding to a significantly elevated overall risk compared with the general U.

More results

Increased risk was observed in both men (standardized incidence ratios 1.81) and women (standardized incidence ratios 1.27).

No significant age-related trend was observed.

“

Conclusion

Young-onset bladder cancer survivors experience a sustained elevation in second primary malignancy risk, underscoring the importance of long-term survivorship awareness and informing counseling and follow-up strategies in this population.

Risk of second primary malignancies after bladder cancer diagnosed at a young age: a SEER population-based analysis.

Risk of second primary malignancies after bladder cancer diagnosed at a young age: a SEER population-based analysis.

Related papers