Immune Repertoire Profiling Reveals Distinct Adaptive Immune Signatures of Dampness ZHENG Across Psoriasis, Rheumatoid Arthritis and Ulcerative Colitis.

A more refined classification of these diseases is essential for enabling targeted therapeutic strategies.

Compared with healthy controls, Ps, rheumatoid arthritis and ulcerative colitis patients exhibited reduced clonotype richness and diminished t cell receptor/b cell receptor diversity, indicating adaptive immune contraction.

Stratification by Dampness ZHENG revealed distinct immune repertoire architectures characterized by increased D50 index, reduced proportions of large clones and preferential V gene usage, including TRAV20, TRAV38-2DV8 and TRAV8-3.