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StudyInternational journal of antimicrobial agents · 2026

Integrated multi-omics profiling reveals the role of the cfa gene in mediating penicillin antibiotics resistance and stress adaptability in Shigella sonnei.

Juan Geng, Yanlei Gao, Wenyao Su … Guangcai Duan

Infectious DiseaseStudy

Removing the cfa gene increases Shigella's ampicillin sensitivity.

Integrated multi-omics profiling reveals the role of the cfa gene in mediating penicillin antibiotics resistance and stress adaptability in Shigella sonnei.

Juan Geng et al. · International journal of antimicrobial agents · 2026

Background

Shigella is the pathogen of bacterial dysentery.

Results

removing the cfa gene made the bacteria much easier to kill with ampicillin

More results

The susceptibility of Res and Δcfa strains to ampicillin was compared, and the molecular regulatory mechanisms of cfa gene on antibiotic resistance in Shigella were explored by screening the differentially expressed mRNAs, proteins, and metabolites of the two groups.

More results

Compared to the Res strain, the Δcfa mutant exhibited a 16-fold increase in susceptibility to amoxicillin, a 16-fold increase in susceptibility to both penicillin and aztreonam, a 4-fold increase in susceptibility to cefotaxime, and a 2-fold increase in susceptibility to cefazolin, ceftazidime, ceftriaxone and tetracycline.

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Conclusion

The cfa gene not only mediates penicillin antibiotics resistance mechanisms in Shigella sonnei but also modulates critical physiological processes.

Post

Integrated multi-omics profiling reveals the role of the cfa gene in mediating penicillin antibiotics resistance and stress adaptability in Shigella sonnei.

Removing the cfa gene increases Shigella's ampicillin sensitivity.

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