Cardiovascular risks in psychiatric disorders and psychiatric risks in cardiovascular disorders…

ReviewJournal of psychosomatic research· Jul 2026

Cardiovascular risks in psychiatric disorders and psychiatric risks in cardiovascular disorders: implications for prevention and clinical management - a large-scale umbrella review encompassing 76 meta-analyses.

Michele Fornaro, Chiara Di Lorenzo, Augusto Esposito, Davide Perona

CardiologyReviewClinical practiceQ2IF 3.1

Major depressive disorder is common in patients with heart failure.

Cardiovascular risks in psychiatric disorders and psychiatric risks in cardiovascular disorders: implications for prevention and clinical management - a large-scale umbrella review encompassing 76 meta-analyses.

Michele Fornaro … Davide Perona

Journal of psychosomatic research · Jul 2026 · Q2 in Psychiatry

Purpose

Psychiatric and cardiovascular disorders often co-occur, complicating their assessment and management.

Methods

Meta-analytic systematic reviews of observational studies documenting the prevalence, risk factors, and outcomes associated with the co-occurrence of cardiovascular and psychiatric disorders, indexed from inception through March.16.2026, and meeting established diagnostic criteria, were included.

n = 76 meta-analyses

Results

41.9%

nearly half of people with a failing heart also experience depression

n = 76 meta-analyses

More results

We included 76 meta-analyses yielding 131 meta-analytic estimates.

Based on pre-existing meta-analytic evidence, 22/24 prevalence estimates (91.7%) met moderate/strong credibility criteria.

Strong credibility emerged for: orthostatic hypotension in Lewy body(58%;95%C.

More results

Several additional disorders were multimorbid in>5% of people, yet with a lower credibility rating.

“

Conclusion

The present study provides an atlas of cardiovascular and psychiatric multimorbidity across varying levels of credibility, reinforcing the need for an integrated, multidisciplinary approach to patient care and for more research on actionable risk/protective factors and outcomes.

Cardiovascular risks in psychiatric disorders and psychiatric risks in cardiovascular disorders: implications for prevention and clinical management - a large-scale umbrella review encompassing 76 meta-analyses.

Cardiovascular risks in psychiatric disorders and psychiatric risks in cardiovascular disorders: implications for prevention and clinical management - a large-scale umbrella review encompassing 76 meta-analyses.

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