marwa farag - research

Mean value of left-and-right-ONSD measurements in control group (0.31 cm, 0.30 cm, respectively) were significantly higher than asphyxiated-group (0.35 cm), with p-value<0.001.

Resistive index (RI) of BA decreased and EDV of BA increased in HIE-patients than healthy-control-neonates, with p value<0.001.

Left-and-right-ONSD diameters are negatively correlated with BA-RI, with r=-.432; p < .01and r=-.34; P.046, respectively.

ONSDs in both eyes, BA-RI and BA-EDV showed significant changes throughout three time points in HIE-patients.

Lung aeration was quantified using a standardized 12-zone LUS protocol (0-3 points per zone) based on international consensus.

ResultsLRM led to significant improvements in oxygenation and lung aeration.

FE demonstrated a significant reduction in TR gradient ( p < 0.001), while SVC flow and RV-MPI remained stable, indicating preserved myocardial function.

Conclusions FiO 2 -guided LRM is effective and safe in late-preterm infants with RDS.

SVCF, velocity-time integral (VTI), and SVC diameter decreased significantly after transfusion (p < 0.001).

ACA peak systolic velocity (PSV), ACA end-diastolic velocity (EDV), and celiac artery PSV also decreased significantly after transfusion (p < 0.001).

Splanchnic and cerebral oxygenation metrics increased significantly, whereas oxygen consumption and fractional tissue oxygen extraction decreased significantly after transfusion (p < 0.001).

Within this group, 49.1% presented with mild, 43.4% with moderate, and 7.5% with severe clinical features, confirming systemic hypoxia despite "normal or near-normal" initial blood gases.

Significant elevations in cardiac Troponin-I and AST were observed in the mild-to-severe classic HIE groups compared to the non-classic cohort ( p < 0.001).

Troponin-I showed high performance (AUC = 0.711) in predicting moderate-to-severe HIE across both cohorts.

The NLR was significantly higher in all infants with clinical evidence of moderate-to-severe hypoxic insult.

The mean (SD) gestational age for the entire group was 29.52 ± 1.05 weeks.

Infants who developed BPD exhibited statistically higher eLUS scores on both day-7 and day-14 afterbirth (P < 0.001).

The eLUS score on day-7 exhibited a strong correlation with invasive mechanical ventilation (IMV) on day-7, the duration of IMV, and oxygen saturation index.

Among the 1105 neonates included in our study, Male patients accounted for 56.4%, with a mean gestational age of 32.67 ± 2.86 weeks.

Early-onset neonatal sepsis (EOS) was detected in 329(29.7%), while late-onset neonatal sepsis (LOS) was detected in 776(70.2%) neonates.

Klebsiella was the predominant pathogen, accounting for 554 (50.1%).

This organism was responsible for 136(24.5%) neonates in 2019, 148(26.7%) neonates in 2020, 137(24.7%) neonates in 2021 and 133(24.0%) neonates in 2022.

The mean (standard deviation) gestational age for the entire population was 29.52 ± 1.05 weeks.

Thirteen neonates (27.1%) among the AZM group developed BPD compared to 14 (31.1%) in the control group ( P = 0.669).

BPD severity at 36 weeks’ PMA and postnatal steroid use showed no significant difference between study groups.

LVO, stroke volume (SV), heart rate (HR), and ACA-peak systolic velocity (PSV) were significantly increased in anemia of prematurity and significantly decreased after RBCs transfusions.

This is a randomized controlled trial that included 80 full-term newborns diagnosed with PPHN within 72 h after birth.

The primary outcome was the estimated systolic pulmonary artery pressure in both groups.

The NNG group exhibited a significant improvement in the oxygenation index and oxygen saturation index (OI&OSI) on days 2 and 3.

The myocardial performance index (MPI), as measured by tissue-Doppler echocardiography, was notably decreased in the NNG group on day 3.