Yuehua Chen - research works

The mean lung mass (760.11 ± 144.89 g) was significantly lower than the 1000-g model (P < 0.001).

Two patients (2%) developed RP, and both had baseline lung metastases (28% overall).

4.3% [range, 1.0-14.5%]).

Lower mDMT had a nonlinear inverse association with multimorbidity (HR = 0.969 per 1℃ increase, 95%CI 0.960-0.978), with a critical 11.3℃ risk threshold and effect modification by age and geographic region.

Findings remained robust across all prespecified sensitivity analyses.

Recognition rates across all seven evaluation dimensions, including interactivity, immediate feedback, and clinical relevance, were significantly higher in the experimental group (all P < 0.05).

Subgroup analysis demonstrated that students with weaker academic foundations benefited most from the intervention, showing the greatest improvement in scores (+12.3 points, P < 0.01).

Five participants (4.2%) harbored pathogenic/likely pathogenic variants in ACMG SF v3.3 genes ( TTN , LDLR , PTEN , RYR1 , TP53 ).

Incidental findings occurred in 51.7%, and at least one recessive-carrier variant was detected in 99.2% (mean 4.15 per individual; median 4).

The Taiwanese-specific c.639+919G>A cardiac Fabry variant accounted for 24/25 confirmed male Fabry cases, and the p.

Gly576Ser pseudodeficiency allele confounded all suspected Pompe cases.

In this study, 89 patients (49.44%) were male and 91 (50.56%) were female.

The median age at surgery was 5.7 years.

66 patients (36.67%) were diagnosed with benign liver neoplasms (BLN), and 114 patients (63.33%) with malignant liver neoplasms (MLN).

The postoperative survival rate was 100% in both groups.

RCA was associated with higher risks of citrate accumulation (RR: 4.67; 95% CI 1.30-16.77) and hypocalcemia (RR: 1.78; 95% CI 1.12-2.83), while acid-base disturbances were not significantly different between groups (RR: 1.34; 95% CI 0.60-3.03).

In addition, RCA significantly reduced major bleeding (RR: 0.37; 95% CI 0.16-0.87), but did not significantly affect the in-hospital mortality (RR: 0.82; 95% CI 0.65-1.04).

Of these, 393 respondents (76.31%) were mothers of the children, and 319 children (61.94%) had suffered from dry eye for less than three months.

Knowledge, attitude, and practice scores were significantly correlated with each other (all P < 0.001).

Mediation analysis showed that knowledge (β = 0.19, P < 0.001), income (β = 0.75, P < 0.001), and marital status (β = 1.63, P = 0.001) were statistically associated with attitude.

Meanwhile, knowledge (β = 0.51, P < 0.001), attitude (β = 0.55, P < 0.001), and residence (β = 1.51, P < 0.001) were statistically associated with practice.

Both treatment groups showed significantly reduced SE and AL progression at 3 and 6 months (all p < 0.001).

IOP decreased in the combination group (-1.75 ± 4.24 mmHg) but increased in the other groups.

Adverse reaction rates were comparable between groups ( p > 0.05).

Among 1,252 children with NDDs, there were 283 cases with pathogenic variants and 219 cases of craniofacial abnormalities.

The positive detection rate of pathogenic variants in the craniofacial anomaly group was significantly higher than that in the overall cohort and the cohort of non-craniofacial anomaly (P < 0.01).

Eyes were the most common craniofacial region with anomalies in children with NDDs carrying pathogenic variants, followed by the head and oral cavity.

Significant differences were observed in the rates of positive characteristics in the eight craniofacial regions between children with NDDs either carrying pathogenic variants or not.

They underwent comprehensive clinical assessment, amyloid PET, and tau PET.

For Alzheimer's disease (AD) diagnosis, tau PET demonstrated high sensitivity (97.8%) and specificity (95.4%), showing substantial agreement with amyloid PET.

In patients clinically diagnosed with non-AD disorders, tau PET led to a significantly higher rate of diagnostic change compared with amyloid PET (p = 0.018).

These findings are descriptive; temporal trends and exposure-outcome associations were not assessed in the present cohort profile.

FUTURE PLANS: The GDPU-OHC will continue prospective follow-up to capture long-term NCD outcomes and repeated occupational health information.