Yael Nisgav - research works

In the study group, staining for tPA was detected in the deep retinal layers in all eyes.

The staining was deeper and more intense at 3 and 24 h than at 48 h.

There was no tPA staining in the retina of eyes injected with saline.

Massive influx of CD11+ inflammatory cells, involving the anterior and posterior chambers, was observed in the murine eyes 24 h after the IL-8 or TNF-α injections.

Cells excreted to their surroundings an extracellular net-like structure positive for NE, MPO, and H3Cit.

H3Cit staining was abolished with the DNase I treatment, indicating the presence of extracellular DNA in the net-like structures.

The etiology of sustained ocular hypertension following intravitreal administration of anti-VEGF agents is yet to be unraveled.

Bevacizumab (25 mg/ml) was injected intravitreally after 3 days.

Donkey anti-human IgG labeled with Alexa Fluor(®) 488 was used for bevacizumab immunoreactivity detection.

Anti-CD31 antibody was used as a marker for Schlemm's canal endothelial cells.