Wei Zhang - research works

In the fully adjusted Cox model, for every 1-unit increase in the CHG index, the risk of new-onset stroke increased by 48% (HR = 1.48, 95% CI: 1.15-1.90, P = 0.003).

However, the restricted cubic spline analysis revealed a significant non-linear relationship (D1 test P = 0.005), with the inflection point occurring at a CHG index of 5.59.

Multivariable logistic regression yielded a consistent significant association (OR = 1.53, 95% CI: 1.16-2.03, P = 0.003).

Subgroup analysis and multiple sensitivity analyses (quartile analysis, exclusion of early stroke events, median binary classification analysis) all supported the robustness of the main findings.

Outcomes included discharge readiness, quality of life (Stroke-Specific Quality of Life [SS-QOL]), functional recovery (Barthel Index, Fugl-Meyer Assessment, National Institutes of Health Stroke Scale), and 30-day readmission rate.

RESULTS The experimental group showed significantly higher discharge-readiness scores (P<0.05), improved SS-QOL at 1 month (171.20±26.21 vs 146.55±31.25; P<0.001) and 3 months (186.25±31.35 vs 150.21±21.34; P<0.001), and better functional outcomes across all scales (all P<0.05).

GT willingness was positively associated with child age under 12 (OR, 1.61; P = 0.019), married status (OR, 5.94; P = 0.016), and IRD-related strife (OR, 3.61; P = 0.014), and negatively with parental severe vision impairment (OR, 0.19; P = 0.012).

Child gender predicted unwillingness rationale ( P = 0.002); parents of males cited apprehension about results, while parents of females cited cost.

Most parents indicated SR unwillingness (NC: 60.3%; ART: 52.2%), with greater willingness toward ART than NC ( P = 0.041).

ThyUS2Path outperformed two commonly state-of-the-art MIL-based methods significantly, namely Maxpool and Meanpool.

The algorithms also obtained good prediction performance in the external test set (AUROCs of 0.70~0.80 and AUPRCs of 0.78~0.83).

Among 2535 enrolled patients, 1414 received NCIT and 1121 received NCRT.

The 2-year DFS rates were 68.7% (NCIT) vs 72.0% (NCRT), and 2-year OS rates were 81.3% vs 83.7%, respectively.

NCIT showed a trend toward improved distant metastasis-free survival (DMFS) (HR, 0.87; 95% CI, 0.69-1.11; P = .27), whereas NCRT was associated with a trend toward improved locoregional recurrence-free survival (LRFS) (HR, 1.22; 95% CI, 0.96-1.56; P = .11).