Sicong Huang - research works

Over the five-year study period, 7,764 students screened positive for suspected scoliosis, of whom 51.6% (n = 4,376) underwent further diagnostic evaluation.

The estimated prevalence of AIS over the five years was 1.08%.

Girls had higher positivity and PPV than boys and a greater proportion of severe cases.

The SSS program in Zhongshan identified students at risk and achieved a high diagnostic yield among those undergoing radiographic evaluation.

One patient died before response assessment because of disease-related gastrointestinal complications.

Cytokine release syndrome occurred for 12 patients (grade 1: n = 8; grade 2: n = 3; grade 3: n = 1), and immune effector cell-associated neurotoxicity syndrome occurred for 2 patients (grade 1: n = 1; grade 2: n = 1).

Robust in vivo CAR T-cell expansion was observed across dose levels, with a median (range) peak expansion of 660.7 (30.7-10 562.3) cells/µL.

At data cutoff, 5 patients experienced a maintained CR and 7 experienced disease relapses or progression (2 with CD19 negative relapses).