OphthalmologyCohort studyDiagnosisQ1IF 3.6
Flow cytometry phenotype matched ocular lymphoma histology in most cases
Alessandra Falda … Daniela Basso
Clinical chemistry and laboratory medicine · Jan 2026 · Q1 in General Medicine
Ocular OncologyStudyTreatmentQ1IF 3.6
Eye overall survival was 48.9% at 5 years in high-risk retinoblastoma eyes.
Eye Salvage and Vision Preservation in High-Risk Intraocular Retinoblastoma Patients: Long-Term Results From the Prospective Phase II AIEOP RTB 012 Study.
Ida Russo … Franco Locatelli
Cancer medicine · Sep 2025
Results
less than half of these high-risk eyes were saved after 5 years
100%
Group A/B
73.3%
Group C
42.5%
Group D
14.3%
Group E
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The 2- and 5-year eye EFS rates were 31.1% (95% CI: 24.4-44.0) and 29.5% (95% CI: 20.4-39.2), respectively.
Ocular survival significantly differed across IIRC groups, with 2- and 5-year survival rates of 100% for group A/B, 86.7% and 73.3% for group C, 65% and 42.5% for group D, and 23.8% and 14.3% for group E, respectively (p < 0.05).
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No severe toxicity was reported.
Among 28 bilateral Rb patients, 12 had VA of at least 20/30 according to the Snellen chart.
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Conclusion
The AIEOP RTB 012 protocol has proven to be both safe and effective, ensuring a favorable final VA.
Ocular OncologyCohort studyPrognosisQ1IF 2.9
Most uveal melanomas carry a GNAQ or GNA11 gene mutation
Immunohistochemical and molecular profiling of uveal melanoma: clinicopathological correlations from an Italian cohort.
Francesco Fortarezza … Angelo Paolo Dei Tos
Pathologica · Dec 2025
Results
83%
gene test found this mutation in most tumors checked
n = 84 UM cases
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Loss of BAP1 expression correlated with epithelioid histology and denser T-cell infiltration yet lacked PD-L1 expression.
Aberrant p53 staining was more frequent in spindle-cell tumors, though TP53 mutations were rare, suggesting functional inactivation through other mechanisms.
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Notably, mutations typically associated with cutaneous melanomas (e.g., BRAF , KIT , CDKN2A ) were also detected, particularly in a single iris melanoma, suggesting site-specific molecular convergence.
Additional recurrent alterations were found in NOTCH1 , PTEN , PIK3CA , and KDR , implicating the mTOR and VEGF signaling pathways.
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Conclusion · 1 of 2
This study highlights the heterogeneous molecular landscape of UM and underscores the importance of integrating histopathological and molecular data for improved prognostic stratification.
Conclusion · 2 of 2
The identification of potential therapeutic targets and atypical mutations typically associated with other melanoma subtypes suggests avenues for future research and tailored therapeutic strategies.